Title |
MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker Assay
|
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Published in |
PLOS ONE, September 2011
|
DOI | 10.1371/journal.pone.0024753 |
Pubmed ID | |
Authors |
Sanne Skovgård Veidal, Morten Asser Karsdal, Efstathios Vassiliadis, Arkadiusz Nawrocki, Martin Røssel Larsen, Quoc Hai Trieu Nguyen, Per Hägglund, Yunyun Luo, Qinlong Zheng, Ben Vainer, Diana Julie Leeming |
Abstract |
During fibrogenesis, in which excessive remodeling of the extracellular matrix occurs, both the quantity of type VI collagen and levels of matrix metalloproteinases, including MMP-2 and MMP-9, increase significantly. Proteolytic degradation of type VI collagen into small fragments, so-called neo-epitopes, may be specific biochemical marker of liver fibrosis. The aim of this study was to develop an ELISA detecting a fragment of type VI collagen generated by MMP-2 and MMP-9, and evaluate this assay in two preclinical models of liver fibrosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 4 | 2% |
Unknown | 161 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 33 | 20% |
Researcher | 29 | 18% |
Student > Master | 21 | 13% |
Other | 14 | 8% |
Student > Bachelor | 13 | 8% |
Other | 29 | 18% |
Unknown | 26 | 16% |
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---|---|---|
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Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Other | 11 | 7% |
Unknown | 35 | 21% |