| Title |
MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker Assay
|
|---|---|
| Published in |
PLOS ONE, September 2011
|
| DOI | 10.1371/journal.pone.0024753 |
| Pubmed ID | |
| Authors |
Sanne Skovgård Veidal, Morten Asser Karsdal, Efstathios Vassiliadis, Arkadiusz Nawrocki, Martin Røssel Larsen, Quoc Hai Trieu Nguyen, Per Hägglund, Yunyun Luo, Qinlong Zheng, Ben Vainer, Diana Julie Leeming |
| Abstract |
During fibrogenesis, in which excessive remodeling of the extracellular matrix occurs, both the quantity of type VI collagen and levels of matrix metalloproteinases, including MMP-2 and MMP-9, increase significantly. Proteolytic degradation of type VI collagen into small fragments, so-called neo-epitopes, may be specific biochemical marker of liver fibrosis. The aim of this study was to develop an ELISA detecting a fragment of type VI collagen generated by MMP-2 and MMP-9, and evaluate this assay in two preclinical models of liver fibrosis. |
Mendeley readers
The data shown below were compiled from readership statistics for 163 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 4 | 2% |
| Unknown | 159 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 20% |
| Researcher | 29 | 18% |
| Student > Master | 21 | 13% |
| Other | 14 | 9% |
| Student > Bachelor | 13 | 8% |
| Other | 27 | 17% |
| Unknown | 26 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 37 | 23% |
| Agricultural and Biological Sciences | 34 | 21% |
| Biochemistry, Genetics and Molecular Biology | 31 | 19% |
| Immunology and Microbiology | 8 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 12 | 7% |
| Unknown | 35 | 21% |