Title |
Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology, and Cognitive Deficits in 3xTg-AD Mice
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Published in |
PLOS ONE, March 2011
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DOI | 10.1371/journal.pone.0017971 |
Pubmed ID | |
Authors |
Carlo Corona, Valerio Frazzini, Elena Silvestri, Rossano Lattanzio, Rossana La Sorda, Mauro Piantelli, Lorella M. T. Canzoniero, Domenico Ciavardelli, Enrico Rizzarelli, Stefano L. Sensi |
Abstract |
The pathogenic road map leading to Alzheimer's disease (AD) is still not completely understood; however, a large body of studies in the last few years supports the idea that beside the classic hallmarks of the disease, namely the accumulation of amyloid-β (Aβ) and neurofibrillary tangles, other factors significantly contribute to the initiation and the progression of the disease. Among them, mitochondria failure, an unbalanced neuronal redox state, and the dyshomeostasis of endogenous metals like copper, iron, and zinc have all been reported to play an important role in exacerbating AD pathology. Given these factors, the endogenous peptide carnosine may be potentially beneficial in the treatment of AD because of its free-radical scavenger and metal chelating properties. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 2% |
United Kingdom | 2 | 1% |
Italy | 1 | <1% |
Japan | 1 | <1% |
Germany | 1 | <1% |
Unknown | 131 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 21 | 15% |
Researcher | 15 | 11% |
Student > Doctoral Student | 14 | 10% |
Student > Bachelor | 11 | 8% |
Professor > Associate Professor | 10 | 7% |
Other | 36 | 26% |
Unknown | 32 | 23% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 32 | 23% |
Medicine and Dentistry | 20 | 14% |
Neuroscience | 13 | 9% |
Biochemistry, Genetics and Molecular Biology | 11 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Other | 23 | 17% |
Unknown | 34 | 24% |