| Title |
Activation of Wnt/β-Catenin Signaling Increases Insulin Sensitivity through a Reciprocal Regulation of Wnt10b and SREBP-1c in Skeletal Muscle Cells
|
|---|---|
| Published in |
PLOS ONE, December 2009
|
| DOI | 10.1371/journal.pone.0008509 |
| Pubmed ID | |
| Authors |
Mounira Abiola, Maryline Favier, Eleni Christodoulou-Vafeiadou, Anne-Lise Pichard, Isabelle Martelly, Isabelle Guillet-Deniau |
| Abstract |
Intramyocellular lipid accumulation is strongly related to insulin resistance in humans, and we have shown that high glucose concentration induced de novo lipogenesis and insulin resistance in murin muscle cells. Alterations in Wnt signaling impact the balance between myogenic and adipogenic programs in myoblasts, partly due to the decrease of Wnt10b protein. As recent studies point towards a role for Wnt signaling in the pathogenesis of type 2 diabetes, we hypothesized that activation of Wnt signaling could play a crucial role in muscle insulin sensitivity. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 3% |
| United Kingdom | 2 | 1% |
| Brazil | 2 | 1% |
| Switzerland | 1 | <1% |
| Mexico | 1 | <1% |
| France | 1 | <1% |
| Unknown | 123 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 24% |
| Researcher | 28 | 21% |
| Student > Master | 12 | 9% |
| Student > Bachelor | 11 | 8% |
| Professor > Associate Professor | 9 | 7% |
| Other | 25 | 19% |
| Unknown | 17 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 47 | 35% |
| Biochemistry, Genetics and Molecular Biology | 30 | 22% |
| Medicine and Dentistry | 18 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Chemistry | 3 | 2% |
| Other | 7 | 5% |
| Unknown | 24 | 18% |