@JimJohnsonSci @SA_Diabetes @ethanjweiss Had to wait until tonight to pull out my dissertation and find the other cool reference. Here it is, done in myotubes. The paper discusses inhibition of WNT signaling and downstream upregulation of the adipogenic pr
@TuckerGoodrich @thermotronica The SREBP pathway is also counter-regulated with the WNT pathway, that promotes insulin receptor expression through the TCF7L2 gene, which is the top diabetes gene from GWAS studies. https://t.co/dKjQEjvcn7
Cc @HowardCen
@DrScottMurray @FatEmperor @JimJohnsonSci @ethanjweiss @DanielJDrucker @puddleg @TheCuriousAhmed @TuckerGoodrich YAS This is my favorite paper on the subject. They demonstrated that SREBP-1C and WNT signaling are counter-regulated. WNT signaling is the mos
@nmlinguaphile @bulkbiker @dbechek1 @kevinnbass @tednaiman Genetically, the leading cause of type 2 is the gene tcf7l2, which among other things, determines whether or not a stem cell differentiates into a fat cell or a muscle cell. Within muscle cells, it
@marqquezine @rmuncy81 @EriksenGrant @jeroen_sluiter @kevinnbass @ProfTimNoakes There it is. SREBP is more activated in insulin resistance, driving the DNL pathway. Now we just need to figure out why SREBP is active. Seems to come along with suppression o
@EricTopol @NEJM @TheLancet @JAMA_current The WNT axis is counter-regulated with the cholesterol synthesis pathway : https://t.co/Bfa4WY7kK8