Title |
Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine
|
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Published in |
PLOS ONE, December 2006
|
DOI | 10.1371/journal.pone.0000079 |
Pubmed ID | |
Authors |
Wataru Sonoyama, Yi Liu, Dianji Fang, Takayoshi Yamaza, Byoung-Moo Seo, Chunmei Zhang, He Liu, Stan Gronthos, Cun-Yu Wang, Songtao Shi, Songlin Wang |
Abstract |
Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Thailand | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 3 | <1% |
Colombia | 2 | <1% |
Brazil | 2 | <1% |
United Kingdom | 2 | <1% |
Iran, Islamic Republic of | 2 | <1% |
Turkey | 1 | <1% |
Germany | 1 | <1% |
Korea, Republic of | 1 | <1% |
Japan | 1 | <1% |
Other | 1 | <1% |
Unknown | 540 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 94 | 17% |
Student > Ph. D. Student | 76 | 14% |
Researcher | 54 | 10% |
Student > Bachelor | 48 | 9% |
Student > Postgraduate | 39 | 7% |
Other | 102 | 18% |
Unknown | 143 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 229 | 41% |
Agricultural and Biological Sciences | 69 | 12% |
Biochemistry, Genetics and Molecular Biology | 35 | 6% |
Engineering | 17 | 3% |
Materials Science | 9 | 2% |
Other | 44 | 8% |
Unknown | 153 | 28% |