| Title |
Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine
|
|---|---|
| Published in |
PLOS ONE, December 2006
|
| DOI | 10.1371/journal.pone.0000079 |
| Pubmed ID | |
| Authors |
Wataru Sonoyama, Yi Liu, Dianji Fang, Takayoshi Yamaza, Byoung-Moo Seo, Chunmei Zhang, He Liu, Stan Gronthos, Cun-Yu Wang, Songtao Shi, Songlin Wang |
| Abstract |
Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Thailand | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 555 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 3 | <1% |
| Colombia | 2 | <1% |
| Brazil | 2 | <1% |
| United Kingdom | 2 | <1% |
| Iran, Islamic Republic of | 2 | <1% |
| Turkey | 1 | <1% |
| Germany | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 539 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 94 | 17% |
| Student > Ph. D. Student | 76 | 14% |
| Researcher | 54 | 10% |
| Student > Bachelor | 48 | 9% |
| Student > Postgraduate | 39 | 7% |
| Other | 100 | 18% |
| Unknown | 144 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 228 | 41% |
| Agricultural and Biological Sciences | 69 | 12% |
| Biochemistry, Genetics and Molecular Biology | 35 | 6% |
| Engineering | 17 | 3% |
| Materials Science | 9 | 2% |
| Other | 42 | 8% |
| Unknown | 155 | 28% |