| Title |
Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study
|
|---|---|
| Published in |
PLOS ONE, August 2008
|
| DOI | 10.1371/journal.pone.0002986 |
| Pubmed ID | |
| Authors |
Patrick Linsel-Nitschke, Anika Götz, Jeanette Erdmann, Ingrid Braenne, Peter Braund, Christian Hengstenberg, Klaus Stark, Marcus Fischer, Stefan Schreiber, Nour Eddine El Mokhtari, Arne Schaefer, Jürgen Schrezenmeier, Diana Rubin, Anke Hinney, Thomas Reinehr, Christian Roth, Jan Ortlepp, Peter Hanrath, Alistair S. Hall, Massimo Mangino, Wolfgang Lieb, Claudia Lamina, Iris M. Heid, Angela Doering, Christian Gieger, Annette Peters, Thomas Meitinger, H.-Erich Wichmann, Inke R. König, Andreas Ziegler, Florian Kronenberg, Nilesh J. Samani, Heribert Schunkert, for the Wellcome Trust Case Control Consortium and the Cardiogenics Consortium |
| Abstract |
Rare mutations of the low-density lipoprotein receptor gene (LDLR) cause familial hypercholesterolemia, which increases the risk for coronary artery disease (CAD). Less is known about the implications of common genetic variation in the LDLR gene regarding the variability of cholesterol levels and risk of CAD. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Taiwan | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 129 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Greece | 1 | <1% |
| Australia | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 124 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 23% |
| Student > Ph. D. Student | 26 | 20% |
| Student > Bachelor | 15 | 12% |
| Student > Master | 11 | 9% |
| Other | 8 | 6% |
| Other | 22 | 17% |
| Unknown | 17 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 37 | 29% |
| Agricultural and Biological Sciences | 34 | 26% |
| Biochemistry, Genetics and Molecular Biology | 17 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Nursing and Health Professions | 3 | 2% |
| Other | 9 | 7% |
| Unknown | 24 | 19% |