Title |
Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation
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Published in |
PLOS ONE, August 2012
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DOI | 10.1371/journal.pone.0042454 |
Pubmed ID | |
Authors |
Romina Nassini, Pamela Pedretti, Nadia Moretto, Camilla Fusi, Chiara Carnini, Fabrizio Facchinetti, Arturo Roberto Viscomi, Anna Rita Pisano, Susan Stokesberry, Charlott Brunmark, Naila Svitacheva, Lorcan McGarvey, Riccardo Patacchini, Anders B. Damholt, Pierangelo Geppetti, Serena Materazzi |
Abstract |
The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism. However the limited clinical evidence for the role of neurogenic inflammation in asthma or chronic obstructive pulmonary disease raises an alternative possibility that airway inflammation is promoted by non-neuronal TRPA1. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | 1% |
Korea, Republic of | 1 | <1% |
Chile | 1 | <1% |
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Unknown | 137 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 22% |
Researcher | 27 | 19% |
Student > Master | 13 | 9% |
Other | 11 | 8% |
Student > Doctoral Student | 9 | 6% |
Other | 27 | 19% |
Unknown | 25 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 34 | 24% |
Medicine and Dentistry | 20 | 14% |
Biochemistry, Genetics and Molecular Biology | 15 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 9% |
Neuroscience | 11 | 8% |
Other | 15 | 10% |
Unknown | 35 | 24% |