Title |
Human Embryonic Stem Cells Differentiated to Lung Lineage-Specific Cells Ameliorate Pulmonary Fibrosis in a Xenograft Transplant Mouse Model
|
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Published in |
PLOS ONE, March 2012
|
DOI | 10.1371/journal.pone.0033165 |
Pubmed ID | |
Authors |
Ena Ray Banerjee, Michael A. Laflamme, Thalia Papayannopoulou, Michael Kahn, Charles E. Murry, William R. Henderson |
Abstract |
Our aim was to differentiate human (h) embryonic stem (ES) cells into lung epithelial lineage-specific cells [i.e., alveolar epithelial type I (AEI) and type II (AEII) cells and Clara cells] as the first step in the development of cell-based strategies to repair lung injury in the bleomycin mouse model of idiopathic pulmonary fibrosis (IPF). A heterogeneous population of non-ciliated lung lineage-specific cells was derived by a novel method of embryoid body (EB) differentiation. This differentiated human cell population was used to modulate the profibrotic phenotype in transplanted animals. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 1% |
Unknown | 87 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 17 | 19% |
Student > Ph. D. Student | 13 | 15% |
Student > Bachelor | 10 | 11% |
Student > Postgraduate | 6 | 7% |
Student > Doctoral Student | 5 | 6% |
Other | 12 | 14% |
Unknown | 25 | 28% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 23 | 26% |
Medicine and Dentistry | 15 | 17% |
Biochemistry, Genetics and Molecular Biology | 11 | 13% |
Engineering | 4 | 5% |
Unspecified | 2 | 2% |
Other | 7 | 8% |
Unknown | 26 | 30% |