@JimJohnsonSci @SA_Diabetes @PaulTitchenell Well, the data I found (unpublished) showed that post-exercise, the most insulin sensitive humans expressed a gene called TRAP (ACP5). I found this paper that showed its overexpression eliminates IR (with obesity
@PeterFaberSP @ZKForTre @FatEmperor @gerdosi The immune system invades fat tissue and then does it's best effort to secrete proinflammatory cytokines that signal the fat cells to become insulin resistant. If you block the cytokines involved, you get an ins
@Meat_Matter_Pod @BioLayne I wouldn't at all say that fat mass is best explained by CICO. It's much better explained by more direct causal factors, like localized inflammatory responses. Check out the figures in this work for example, with similar foodtake
@NigelKinbrum @nmlinguaphile @dbechek1 @kevinnbass @tednaiman Diabetics have large numbers of inflammatory macrophages that invade tissues, secrete cytokines, and promote insulin resistance. There's a key gene that shuts this off & when overexpressed c