Title |
Phenotypic Covariance of Longevity, Immunity and Stress Resistance in the Caenorhabditis Nematodes
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Published in |
PLOS ONE, April 2010
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DOI | 10.1371/journal.pone.0009978 |
Pubmed ID | |
Authors |
Francis R. G. Amrit, Claudia M. L. Boehnisch, Robin C. May |
Abstract |
Ageing, immunity and stresstolerance are inherent characteristics of all organisms. In animals, these traits are regulated, at least in part, by forkhead transcription factors in response to upstream signals from the Insulin/Insulin-like growth factor signalling (IIS) pathway. In the nematode Caenorhabditis elegans, these phenotypes are molecularly linked such that activation of the forkhead transcription factor DAF-16 both extends lifespan and simultaneously increases immunity and stress resistance. It is known that lifespan varies significantly among the Caenorhabditis species but, although DAF-16 signalling is highly conserved, it is unclear whether this phenotypic linkage occurs in other species. Here we investigate this phenotypic covariance by comparing longevity, stress resistance and immunity in four Caenorhabditis species. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 2% |
United States | 2 | 2% |
Hungary | 1 | 1% |
Germany | 1 | 1% |
Unknown | 79 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 24 | 28% |
Student > Ph. D. Student | 18 | 21% |
Other | 8 | 9% |
Student > Bachelor | 7 | 8% |
Professor > Associate Professor | 6 | 7% |
Other | 12 | 14% |
Unknown | 10 | 12% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 45 | 53% |
Biochemistry, Genetics and Molecular Biology | 14 | 16% |
Medicine and Dentistry | 3 | 4% |
Neuroscience | 3 | 4% |
Immunology and Microbiology | 2 | 2% |
Other | 6 | 7% |
Unknown | 12 | 14% |