Involvement of Sigma-1 Receptors in the Antidepressant-like Effects of Dextromethorphan https://t.co/OMTFDYG6qG "In addition to binding to NMDA receptors, dextromethorphan binds to sigma-1 (σ1) receptors"
Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan - PubMed https://t.co/J7ZiwJHCTX
@AngelaReiersen @JillPad1 @stkirsch Anybody look into dextromethorphan? https://t.co/J7ZiwJHCTX
RT @CAMM29160: Re-upping this re: $AXSM because surprised there is any question. Competitor's deuterated DM does not demonstrate bioactivit…
RT @CAMM29160: Re-upping this re: $AXSM because surprised there is any question. Competitor's deuterated DM does not demonstrate bioactivit…
RT @CAMM29160: Re-upping this re: $AXSM because surprised there is any question. Competitor's deuterated DM does not demonstrate bioactivit…
Re-upping this re: $AXSM because surprised there is any question. Competitor's deuterated DM does not demonstrate bioactivity on the two major pathways DM hits - NMDA & Sigma-1. That has been proved. https://t.co/gF9oolMaGm https://t.co/oMbE3wwKAu htt
@AF_biotech Here are some relevant studies $AXSM $AVNR https://t.co/8Q7u0lcCxo https://t.co/wh1GbQlAe0 https://t.co/USC6YuPaI1
BIG DIFFERNCES of $AXSM NON-DEUTERATED DM/BUP vs $CNCE DEUTERATED DM/Q 5mg AXS-05 DM AUC 2x AVP-786 & IMPORTANTLY, some thought deuteration has full pharmacodynamic activity but this data suggests otherwise. Specifically, w/ respect to sigma-1 and AMPA
$AXSM is down likely due to the failure of Otsuka's deuterated DM. These preclinical data definitively show that the deuterated formulation does not address the NMDA and sigma-1 pathways. Pretty clear: https://t.co/gF9oolMaGm https://t.co/oMbE3wwKAu http
@Jdalexander64 Pre-clinical data shows clear differences in mechanism of action as between deuterated DM and DM (as used by $AXSM). https://t.co/gF9oolMaGm https://t.co/oMbE3wwKAu https://t.co/2q0fESVwW2
RT @CAMM29160: @BIOBETTER @Jdalexander64 @YoungChris27040 @BillMiller32 these preclinical data clearly show difference in two key moa's for…
RT @CAMM29160: $AXSM There are pre-clinical data that clearly show the deuterated formulation does not have the same effect on the two main…
RT @CAMM29160: $AXSM There are pre-clinical data that clearly show the deuterated formulation does not have the same effect on the two main…
$AXSM There are pre-clinical data that clearly show the deuterated formulation does not have the same effect on the two main mechanisms of action of un-deuterated dextromethorphan. https://t.co/gF9oolMaGm https://t.co/oMbE3wwKAu https://t.co/2q0fESVwW2
@BIOBETTER @Jdalexander64 @YoungChris27040 @BillMiller32 these preclinical data clearly show difference in two key moa's for deuterated DM: https://t.co/gF9oolMaGm https://t.co/oMbE3wwKAu https://t.co/2q0fESVwW2
@Jdalexander64 @AF_biotech He knows better than I, but these preclinical studies clearly suggest that AMPA and σ1 receptor pathway activity using the deuterated version are attenuated w/ AMPA & σ1 receptor antagonists, respectively. https://t.co/oMbE3w
@Jdalexander64 And here are three pre-clinical studies that demonstrate that deuteration affects mechanism of action: https://t.co/gF9oolMaGm https://t.co/oMbE3wwKAu https://t.co/2q0fESVwW2
Efectos antidepresivos del dextrometorfano. http://t.co/GFzQj2EJ33