Title |
Arginine Metabolism by Macrophages Promotes Cardiac and Muscle Fibrosis in mdx Muscular Dystrophy
|
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Published in |
PLOS ONE, May 2010
|
DOI | 10.1371/journal.pone.0010763 |
Pubmed ID | |
Authors |
Michelle Wehling-Henricks, Maria C. Jordan, Tomomi Gotoh, Wayne W. Grody, Kenneth P. Roos, James G. Tidball |
Abstract |
Duchenne muscular dystrophy (DMD) is the most common, lethal disease of childhood. One of 3500 new-born males suffers from this universally-lethal disease. Other than the use of corticosteroids, little is available to affect the relentless progress of the disease, leading many families to use dietary supplements in hopes of reducing the progression or severity of muscle wasting. Arginine is commonly used as a dietary supplement and its use has been reported to have beneficial effects following short-term administration to mdx mice, a genetic model of DMD. However, the long-term effects of arginine supplementation are unknown. This lack of knowledge about the long-term effects of increased arginine metabolism is important because elevated arginine metabolism can increase tissue fibrosis, and increased fibrosis of skeletal muscles and the heart is an important and potentially life-threatening feature of DMD. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 2% |
Switzerland | 1 | <1% |
Netherlands | 1 | <1% |
Italy | 1 | <1% |
Norway | 1 | <1% |
Canada | 1 | <1% |
United States | 1 | <1% |
Unknown | 94 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 25 | 25% |
Researcher | 20 | 20% |
Student > Master | 12 | 12% |
Professor > Associate Professor | 7 | 7% |
Professor | 6 | 6% |
Other | 19 | 19% |
Unknown | 13 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 30% |
Biochemistry, Genetics and Molecular Biology | 17 | 17% |
Medicine and Dentistry | 14 | 14% |
Engineering | 6 | 6% |
Neuroscience | 3 | 3% |
Other | 11 | 11% |
Unknown | 20 | 20% |