RT @antigenomics: @sebboeg @iskander What you ask is are those epitopes immunogenic. While HLA binding prediction is very accurate these da…
@sebboeg @iskander What you ask is are those epitopes immunogenic. While HLA binding prediction is very accurate these days, telling if a given epitope is immunogenic or not is extremely hard (see e.g. https://t.co/61HMLVLhnX), so validation is required as
CD4+/CD8+ immunogenicity models were logistic regressions with forward feature selection. Features were MHC affinity, mass spec presentation score, MHCflurry processing (for CD8+) and amino acid properties from https://t.co/uQeP5OzZYB (e.g. smaller AAs =
@VesteinnThors I wish I had such a list :) There are a few possibly relevant papers out there including https://t.co/Qi3aFg2pUk
Properties of MHC Class I Presented Peptides That Enhance Immunogenicity http://t.co/vaNMjWhfS1
Properties of MHC Class I Presented Peptides That Enhance Immunogenicity http://t.co/OF0hZt4dkx Science.alltop