| Title |
In-Vitro Helix Opening of M. tuberculosis oriC by DnaA Occurs at Precise Location and Is Inhibited by IciA Like Protein
|
|---|---|
| Published in |
PLOS ONE, January 2009
|
| DOI | 10.1371/journal.pone.0004139 |
| Pubmed ID | |
| Authors |
Sandeep Kumar, Aisha Farhana, Seyed E. Hasnain |
| Abstract |
Mycobacterium tuberculosis (M.tb), the pathogen that causes tuberculosis, is capable of staying asymptomatically in a latent form, persisting for years in very low replicating state, before getting reactivated to cause active infection. It is therefore important to study M.tb chromosome replication, specifically its initiation and regulation. While the region between dnaA and dnaN gene is capable of autonomous replication, little is known about the interaction between DnaA initiator protein, oriC origin of replication sequences and their negative effectors of replication. |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 4% |
| Denmark | 1 | 2% |
| Germany | 1 | 2% |
| Unknown | 41 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 24% |
| Student > Ph. D. Student | 9 | 20% |
| Professor > Associate Professor | 6 | 13% |
| Student > Master | 3 | 7% |
| Unspecified | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 10 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 40% |
| Biochemistry, Genetics and Molecular Biology | 9 | 20% |
| Unspecified | 2 | 4% |
| Immunology and Microbiology | 2 | 4% |
| Arts and Humanities | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 10 | 22% |