RT @quay_dr: In 2013 Lawrence Livermore Labs did GoF serial passage to convert a cow coronavirus to a human pathogen What happened? A SARS…
Recombination = Intelligent Design == 'ugly' 'Natural' Selection (in vaccine reseearch leak) = 'beautiful' @ydeigin @gdemaneuf @billybostickson @MJnanostretch https://t.co/br4XNnIAV2 https://t.co/hrQ9zTynl5
RT @peter_berghmans: @magi_jay Andersen admits the 12nt insertion could have been added via gibson assembly AFTER publication. https://t.co…
RT @peter_berghmans: @magi_jay Andersen admits the 12nt insertion could have been added via gibson assembly AFTER publication. https://t.co…
@magi_jay Andersen admits the 12nt insertion could have been added via gibson assembly AFTER publication. https://t.co/CiGvi5njuA
@MartinaSisters @VBruttel Further relevant studies https://t.co/f4pi4JtW3i https://t.co/PcrYfDaYYA https://t.co/ZEEsneCw65
RT @LDjaparidze: @emmecola @stuartjdneil @MJnanostretch @BallouxFrancois @BenFPiercePhD Already done in 2013. In this cow coronavirus the…
@gglinskii Yes which is the argument against it having happened in bats (where it's considered not advantageous and even detrimental). But it could end up present in a subpopulation and then have its day in the sun once it finds a human. https://t.co/Ctds
RT @quay_dr: In 2013 Lawrence Livermore Labs did GoF serial passage to convert a cow coronavirus to a human pathogen What happened? A SARS…
RT @quay_dr: In 2013 Lawrence Livermore Labs did GoF serial passage to convert a cow coronavirus to a human pathogen What happened? A SARS…
RT @quay_dr: If u can get furin site by serial passage & lab insertion how do you distinguish the processes? Codon usage: Serial passage…
RT @quay_dr: If u can get furin site by serial passage & lab insertion how do you distinguish the processes? Codon usage: Serial passage…
RT @quay_dr: If u can get furin site by serial passage & lab insertion how do you distinguish the processes? Codon usage: Serial passage…
RT @quay_dr: If u can get furin site by serial passage & lab insertion how do you distinguish the processes? Codon usage: Serial passage…
RT @quay_dr: In 2013 Lawrence Livermore Labs did GoF serial passage to convert a cow coronavirus to a human pathogen What happened? A SARS…
RT @quay_dr: In 2013 Lawrence Livermore Labs did GoF serial passage to convert a cow coronavirus to a human pathogen What happened? A SARS…
RT @quay_dr: If u can get furin site by serial passage & lab insertion how do you distinguish the processes? Codon usage: Serial passage…
RT @quay_dr: In 2013 Lawrence Livermore Labs did GoF serial passage to convert a cow coronavirus to a human pathogen What happened? A SARS…
RT @quay_dr: If u can get furin site by serial passage & lab insertion how do you distinguish the processes? Codon usage: Serial passage…
@mbw61567742 @BiophysicsFL @DavidBahry @Rebecca21951651 @realZenelan @EmaNymton90 @davideyoungmd @murraygilman @Biorealism @TheBitterPill1 @whstancil Yes and it would have only had about 3 days before his immune system whacked it. However, the FCS might ha
@mbw61567742 Assuming FCS is really as detrimental as claimed in bats. You could also have a proto-FCS that conferred some function. Or a subpopulation with an FCS waiting for its day in the sun. But the most important point here is to acknowledge our igno
RT @gadboit: as was found in this experiment with bovine coronaviruses. And of course it is still possible that this is just contamination…
as was found in this experiment with bovine coronaviruses. And of course it is still possible that this is just contamination with human SC2 from 2020 (although 8782T speaks against that). So we don't know... https://t.co/CtdstROly4
@andrewtanyongyi @NicoDelon @ewinsberg You mean the possibility of passaging a virus where there was already a subpopulation that had the FCS? Yes this is possible. The FCS does appear in the raw reads of one of the Pangolin viruses. But it may well just b
@humblesci Agreed, but then this thought occurred to me: https://t.co/ZqGu6OTXvB
Actually what if P2S isn't contaminated with SC2 either, but the FCS was present, but rare, in a subpopulation (as in the BCoV in the paper below)? This would be a major discovery about the origin of the FCS. Does anyone know where I can get the full... h
@stevenemassey @Rebecca21951651 @bXLpedestrian @peter_berghmans @DrHermiz @magi_jay @mbalter @RobertFGarry1 @VBruttel @Ayjchan It seems (to me at least) to be evidence against passaging being the cause of the insert as well, if this particular study is re
@emmecola @stuartjdneil @MJnanostretch @BallouxFrancois @BenFPiercePhD Already done in 2013. In this cow coronavirus the FCS wasn't found in the consensus sequence, but it was already present in very low prevalence, it acquired an FCS at the S1/S2 junctio
@BiophysicsFL @Biorealism @witmiller @NanoHydraulic @NateSilver538 @JamesSurowiecki Even a month after the PO was published Andersen just kept bringing that part up, citing this paper: https://t.co/fWfWzxFTSU
RT @intriguedpeter: @Ticklicker56 @dorkmo @Muller_Lab @gdemaneuf @antonioregalado @jepekar Correction. Eloit does not find FCS in serial pa…
@newtecher @NateSilver538 They may not have used "a specific sequence". Passaging BCoVs through various cell lines seems to induce an Arg heavy (the R in PRRA) 12nt insert near S1/S2 as an adaptive mutation. Just like SC2 https://t.co/HDrs1DU9Qo
"Adapting Bovine Coronavirus to New Host Environments" i.e. humans (2012) Anpassung von Rinder-#Coronavirus an neue Wirte, also Menschen.
@Ticklicker56 @dorkmo @Muller_Lab @gdemaneuf @antonioregalado @jepekar Correction. Eloit does not find FCS in serial passage experiments, but there is a group of researchers that identified FCS insert in bovine betaCovs in passage experiments... https://t
RT @BiophysicsFL: Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJv…
@ernestorr @BallouxFrancois That's not true. DEFUSE proposing FCS inserts and then the first sarbecovirus with a FCS emerges from nowhere with human typical codons, proximity, reporting on 1st cases, etc. Incidentally, passaging can reliably cause a 12nt
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @BiophysicsFL: Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJv…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @mentju4: @BiophysicsFL yes. in 3 SEPARATE experiments. https://t.co/QjvayPE2rh
RT @BiophysicsFL: Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJv…
RT @pizzapicklespur: 👇🏻
RT @BiophysicsFL: Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJv…
RT @pizzapicklespur: 👇🏻
RT @pizzapicklespur: 👇🏻
👇🏻
RT @BiophysicsFL: Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJv…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @Harvard2H: This was documented three years ago. If this guy wasn't a useless idiot, he could've cited my paper, three fucking years a…
RT @BiophysicsFL: Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJv…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @mentju4: @BiophysicsFL yes. in 3 SEPARATE experiments. https://t.co/QjvayPE2rh
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
@WashburneAlex @Biorealism @HansMahncke @Ayjchan @ydeigin @Rossana38510044 Well, Andersen says that it may be 'context dependent'. He shared a study in which serial passaging led exactly to an insert of 12 nucleotides, of which three codons coded for argin
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @BiophysicsFL: Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJv…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @BiophysicsFL: Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJv…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @Harvard2H: This was documented three years ago. If this guy wasn't a useless idiot, he could've cited my paper, three fucking years a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @BiophysicsFL: Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJv…
@harishseshadri2 @humblesci @gdemaneuf @edwardcholmes They clearly didn't. Shortly after PO, Andersen posted this in the slack thread concerned about passaging causing a 12nt insertion in BCoVs, reliably including R codons. Even pushing back on Eddie a bi
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @Harvard2H: This was documented three years ago. If this guy wasn't a useless idiot, he could've cited my paper, three fucking years a…
RT @coreyum: @Biorealism Not to mention passaging BCoVs seems to magically insert 12nt heavy in Arg codons at S1/S2. Andersen found this l…
RT @BiophysicsFL: Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJv…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
@Biorealism Not to mention passaging BCoVs seems to magically insert 12nt heavy in Arg codons at S1/S2. Andersen found this little nugget. Interesting read. https://t.co/HDrs1DU9Qo
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
RT @Harvard2H: This was documented three years ago. If this guy wasn't a useless idiot, he could've cited my paper, three fucking years a…
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
This was documented three years ago. If this guy wasn't a useless idiot, he could've cited my paper, three fucking years ago.
RT @jbkinney: Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a…
Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis. This one's a gem.
Andersen's Slack messages are legit a great source for scientific references supporting the lab-leak hypothesis.
@BiophysicsFL yes. in 3 SEPARATE experiments. https://t.co/QjvayPE2rh
RT @BiophysicsFL: Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJv…
RT @BiophysicsFL: Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJv…
Here is the serial passaging experiment that added a 12 nt insert into a BetaCoV, leading to SRRR. https://t.co/Sjl7JVJvqK https://t.co/l1UquBWLD1
on april 16th 2020, @K_G_Andersen is still concerned about a lab origin of the virus. he cites shi zhengli's behavior, passaging experiments that resulted in a 12 nucelotide insert: https://t.co/ciQImF8AQl & possible gibson assembly. 👀 @WashburneAlex
Kristian was second-guessing himself (in april 2020) because 3 different naturally infected bovine nasal samples acquired 12 nucleotides when serially passaged while none of the un-passaged samples did. https://t.co/yQ9MxKkNnD https://t.co/ciQImF8AQl htt
RT @Muller_Lab: @CD57227 It's nice to have this spelled out so clearly by ostensible "opponents" of the lab leak scenarios. https://t.co/O…
RT @quay_dr: In 2013 Lawrence Livermore Labs did GoF serial passage to convert a cow coronavirus to a human pathogen What happened? A SARS…
RT @Muller_Lab: @CD57227 It's nice to have this spelled out so clearly by ostensible "opponents" of the lab leak scenarios. https://t.co/O…
@CD57227 It's nice to have this spelled out so clearly by ostensible "opponents" of the lab leak scenarios. https://t.co/Ohk3irxjDH
@BiophysicsFL @XinWei57337546 Based on this we might hypothetically be able to find small numbers of mutants already with an FCS in samples of bat viruses. I've never heard this reported though. https://t.co/ZtlPGumIMY