Title |
Calcium Wave Propagation in Networks of Endothelial Cells: Model-based Theoretical and Experimental Study
|
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Published in |
PLoS Computational Biology, December 2012
|
DOI | 10.1371/journal.pcbi.1002847 |
Pubmed ID | |
Authors |
Juexuan Long, Michael Junkin, Pak Kin Wong, James Hoying, Pierre Deymier |
Abstract |
In this paper, we present a combined theoretical and experimental study of the propagation of calcium signals in multicellular structures composed of human endothelial cells. We consider multicellular structures composed of a single chain of cells as well as a chain of cells with a side branch, namely a "T" structure. In the experiments, we investigate the result of applying mechano-stimulation to induce signaling in the form of calcium waves along the chain and the effect of single and dual stimulation of the multicellular structure. The experimental results provide evidence of an effect of architecture on the propagation of calcium waves. Simulations based on a model of calcium-induced calcium release and cell-to-cell diffusion through gap junctions shows that the propagation of calcium waves is dependent upon the competition between intracellular calcium regulation and architecture-dependent intercellular diffusion. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 4% |
Unknown | 49 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 22% |
Student > Ph. D. Student | 10 | 20% |
Professor > Associate Professor | 8 | 16% |
Student > Bachelor | 5 | 10% |
Student > Master | 5 | 10% |
Other | 7 | 14% |
Unknown | 5 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 31% |
Engineering | 10 | 20% |
Physics and Astronomy | 6 | 12% |
Medicine and Dentistry | 4 | 8% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Other | 6 | 12% |
Unknown | 7 | 14% |