Title |
Recapitulation of Tumor Heterogeneity and Molecular Signatures in a 3D Brain Cancer Model with Decreased Sensitivity to Histone Deacetylase Inhibition
|
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Published in |
PLOS ONE, December 2012
|
DOI | 10.1371/journal.pone.0052335 |
Pubmed ID | |
Authors |
Stuart J. Smith, Martin Wilson, Jennifer H. Ward, Cheryl V. Rahman, Andrew C. Peet, Donald C. Macarthur, Felicity R. A. J. Rose, Richard G. Grundy, Ruman Rahman |
Abstract |
Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated using the 3D Rotary Cell Culture System (RCCS). |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 131 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 35 | 27% |
Researcher | 23 | 17% |
Student > Master | 15 | 11% |
Student > Doctoral Student | 10 | 8% |
Student > Bachelor | 10 | 8% |
Other | 16 | 12% |
Unknown | 23 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 27 | 20% |
Biochemistry, Genetics and Molecular Biology | 24 | 18% |
Medicine and Dentistry | 20 | 15% |
Engineering | 10 | 8% |
Neuroscience | 4 | 3% |
Other | 21 | 16% |
Unknown | 26 | 20% |