CK2-Mediated Hyperphosphorylation of Topoisomerase I Targets Serine 506, Enhances Topoisomerase I–DNA Binding, and Increases Cellular Camptothecin Sensitivity

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Open Access, 22 Nov 2012

by Keya Bandyopadhyay, Pingchuan Li, Ruth A. Gjerset Topoisomerase I is the target for a potent class of chemotherapeutic drugs…