Title |
Inflammatory Cascades Driven by Tumor Necrosis Factor-Alpha Play a Major Role in the Progression of Acute Liver Failure and Its Neurological Complications
|
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Published in |
PLOS ONE, November 2012
|
DOI | 10.1371/journal.pone.0049670 |
Pubmed ID | |
Authors |
Anne Chastre, Mireille Bélanger, Elizabeth Beauchesne, Bich N. Nguyen, Paul Desjardins, Roger F. Butterworth |
Abstract |
Acute liver failure (ALF) due to ischemic or toxic liver injury is a clinical condition that results from massive loss of hepatocytes and may lead to hepatic encephalopathy (HE), a serious neuropsychiatric complication. Although increased expression of tumor necrosis factor-alpha (TNF-α) in liver, plasma and brain has been observed, conflicting results exist concerning its roles in drug-induced liver injury and on the progression of HE. The present study aimed to investigate the therapeutic value of etanercept, a TNF-α neutralizing molecule, on the progression of liver injury and HE in mice with ALF resulting from azoxymethane (AOM) hepatotoxicity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | 5% |
Lebanon | 1 | 2% |
France | 1 | 2% |
Canada | 1 | 2% |
Unknown | 54 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 18% |
Student > Master | 9 | 15% |
Student > Ph. D. Student | 9 | 15% |
Student > Doctoral Student | 6 | 10% |
Student > Bachelor | 6 | 10% |
Other | 8 | 13% |
Unknown | 11 | 18% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 9 | 15% |
Neuroscience | 6 | 10% |
Nursing and Health Professions | 2 | 3% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Other | 9 | 15% |
Unknown | 12 | 20% |