@eperlste @WaveLifeSci @HDBuzzFeed This is worth a look, suggests somatic instability might be the key driver of onset, though a little agnostic on the actual mechanism of tox: https://t.co/QFMJxCRX3u

@JankovicJoseph @bcmhouston But it's consistent with a proposal from Ehud Shapiro and Shai Kaplan @WeizmannScience, who propose that somatic instability of long trinucleotide repeats drives pathogenesis. Maybe even "intermediate" alleles could occasionally