Chronic Activation of the G Protein-Coupled Receptor 30 with Agonist G-1 Attenuates Heart Failure

Overview of attention for article published in PLOS ONE, October 2012

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心不全ラットモデルでGPR30作動薬G-1の薬効を評価。G-1はBNP濃度・心臓線維化を抑制、心臓の収縮を増強した。さらにG-1による慢性的受容体活性化はβ1ARの発現を正常化しβ2AR発現を増加させて心不全を改善する可能性が示唆された。http://t.co/rC1AmWw1

Chronic Activation of the G Protein-Coupled Receptor 30 with Agonist G-1 Attenuates Heart Failure http://t.co/omk86MdS