| Title |
Effects of Beta-Alanine Supplementation on Brain Homocarnosine/Carnosine Signal and Cognitive Function: An Exploratory Study
|
|---|---|
| Published in |
PLOS ONE, April 2015
|
| DOI | 10.1371/journal.pone.0123857 |
| Pubmed ID | |
| Authors |
Marina Yazigi Solis, Simon Cooper, Ruth M Hobson, Guilherme G Artioli, Maria C Otaduy, Hamilton Roschel, Jacques Robertson, Daniel Martin, Vitor S Painelli, Roger C Harris, Bruno Gualano, Craig Sale |
| Abstract |
Two independent studies were conducted to examine the effects of 28 d of beta-alanine supplementation at 6.4 g d-1 on brain homocarnosine/carnosine signal in omnivores and vegetarians (Study 1) and on cognitive function before and after exercise in trained cyclists (Study 2). In Study 1, seven healthy vegetarians (3 women and 4 men) and seven age- and sex-matched omnivores undertook a brain 1H-MRS exam at baseline and after beta-alanine supplementation. In study 2, nineteen trained male cyclists completed four 20-Km cycling time trials (two pre supplementation and two post supplementation), with a battery of cognitive function tests (Stroop test, Sternberg paradigm, Rapid Visual Information Processing task) being performed before and after exercise on each occasion. In Study 1, there were no within-group effects of beta-alanine supplementation on brain homocarnosine/carnosine signal in either vegetarians (p = 0.99) or omnivores (p = 0.27); nor was there any effect when data from both groups were pooled (p = 0.19). Similarly, there was no group by time interaction for brain homocarnosine/carnosine signal (p = 0.27). In study 2, exercise improved cognitive function across all tests (P<0.05), although there was no effect (P>0.05) of beta-alanine supplementation on response times or accuracy for the Stroop test, Sternberg paradigm or RVIP task at rest or after exercise. 28 d of beta-alanine supplementation at 6.4g d-1 appeared not to influence brain homocarnosine/carnosine signal in either omnivores or vegetarians; nor did it influence cognitive function before or after exercise in trained cyclists. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 50% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Scientists | 2 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | <1% |
| Unknown | 100 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 25 | 25% |
| Student > Bachelor | 15 | 15% |
| Student > Ph. D. Student | 11 | 11% |
| Researcher | 9 | 9% |
| Student > Postgraduate | 5 | 5% |
| Other | 14 | 14% |
| Unknown | 22 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 25 | 25% |
| Medicine and Dentistry | 16 | 16% |
| Agricultural and Biological Sciences | 8 | 8% |
| Biochemistry, Genetics and Molecular Biology | 6 | 6% |
| Nursing and Health Professions | 4 | 4% |
| Other | 16 | 16% |
| Unknown | 26 | 26% |