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Noninvasive Image Texture Analysis Differentiates K-ras Mutation from Pan-Wildtype NSCLC and Is Prognostic

Overview of attention for article published in PLOS ONE, July 2014
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Title
Noninvasive Image Texture Analysis Differentiates K-ras Mutation from Pan-Wildtype NSCLC and Is Prognostic
Published in
PLOS ONE, July 2014
DOI 10.1371/journal.pone.0100244
Pubmed ID
Authors

Glen J. Weiss, Balaji Ganeshan, Kenneth A. Miles, David H. Campbell, Philip Y. Cheung, Samuel Frank, Ronald L. Korn

Abstract

Non-invasive characterization of a tumor's molecular features could enhance treatment management. Quantitative computed tomography (CT) based texture analysis (QTA) has been used to derive tumor heterogeneity information, and the appearance of the tumors has been shown to relate to patient outcome in non-small cell lung cancer (NSCLC) and other cancers. In this study, we examined the potential of tumoral QTA to differentiate K-ras mutant from pan-wildtype tumors and its prognostic potential using baseline pre-treatment non-contrast CT imaging in NSCLC.

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Geographical breakdown

Country Count As %
Netherlands 1 <1%
United States 1 <1%
Unknown 108 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 19%
Student > Master 17 15%
Researcher 13 12%
Other 11 10%
Student > Doctoral Student 10 9%
Other 18 16%
Unknown 20 18%
Readers by discipline Count As %
Medicine and Dentistry 52 47%
Computer Science 6 5%
Engineering 6 5%
Physics and Astronomy 4 4%
Agricultural and Biological Sciences 3 3%
Other 10 9%
Unknown 29 26%