Title |
The Nuclear Receptor REV-ERBα Regulates Fabp7 and Modulates Adult Hippocampal Neurogenesis
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Published in |
PLOS ONE, June 2014
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DOI | 10.1371/journal.pone.0099883 |
Pubmed ID | |
Authors |
Anna Schnell, Sylvie Chappuis, Isabelle Schmutz, Emanuele Brai, Jürgen A. Ripperger, Olivier Schaad, Hans Welzl, Patrick Descombes, Lavinia Alberi, Urs Albrecht |
Abstract |
The function of the nuclear receptor Rev-erbα (Nr1d1) in the brain is, apart from its role in the circadian clock mechanism, unknown. Therefore, we compared gene expression profiles in the brain between wild-type and Rev-erbα knock-out (KO) animals. We identified fatty acid binding protein 7 (Fabp7, Blbp) as a direct target of repression by REV-ERBα. Loss of Rev-erbα manifested in memory and mood related behavioral phenotypes and led to overexpression of Fabp7 in various brain areas including the subgranular zone (SGZ) of the hippocampus, where neuronal progenitor cells (NPCs) can initiate adult neurogenesis. We found increased proliferation of hippocampal neurons and loss of its diurnal pattern in Rev-erbα KO mice. In vitro, proliferation and migration of glioblastoma cells were affected by manipulating either Fabp7 expression or REV-ERBα activity. These results suggest an important role of Rev-erbα and Fabp7 in adult neurogenesis, which may open new avenues for treatment of gliomas as well as neurological diseases such as depression and Alzheimer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Canada | 2 | 2% |
Spain | 1 | <1% |
South Africa | 1 | <1% |
Unknown | 105 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 23 | 21% |
Researcher | 23 | 21% |
Student > Bachelor | 11 | 10% |
Student > Doctoral Student | 8 | 7% |
Student > Master | 6 | 5% |
Other | 18 | 16% |
Unknown | 22 | 20% |
Readers by discipline | Count | As % |
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Neuroscience | 25 | 23% |
Agricultural and Biological Sciences | 24 | 22% |
Biochemistry, Genetics and Molecular Biology | 19 | 17% |
Medicine and Dentistry | 8 | 7% |
Psychology | 6 | 5% |
Other | 4 | 4% |
Unknown | 25 | 23% |