| Title |
Relative Hypo- and Hypercortisolism Are Both Associated with Depression and Lower Quality of Life in Bipolar Disorder: A Cross-Sectional Study
|
|---|---|
| Published in |
PLOS ONE, June 2014
|
| DOI | 10.1371/journal.pone.0098682 |
| Pubmed ID | |
| Authors |
Martin Maripuu, Mikael Wikgren, Pontus Karling, Rolf Adolfsson, Karl-Fredrik Norrback |
| Abstract |
Depression in unipolar and bipolar disorders is associated with hypothalamic-pituitary-adrenal-axis (HPA-axis) hyperactivity. Also, unipolar disorder has recently been shown to exhibit HPA-axis hypoactivity. We studied for the first time how HPA-axis hypo- and hyperactivity relate to depression and disease burden in bipolar disorder. We were interested in studying hypocortisolism; characterized by increased HPA-axis negative feedback sensitivity and lower basal cortisol levels together with the opposite HPA-axis regulatory pattern of hypercortisolism. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 96 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 17% |
| Student > Bachelor | 16 | 16% |
| Student > Master | 16 | 16% |
| Researcher | 10 | 10% |
| Student > Postgraduate | 7 | 7% |
| Other | 13 | 13% |
| Unknown | 19 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 20 | 20% |
| Medicine and Dentistry | 14 | 14% |
| Agricultural and Biological Sciences | 14 | 14% |
| Nursing and Health Professions | 7 | 7% |
| Neuroscience | 7 | 7% |
| Other | 8 | 8% |
| Unknown | 28 | 29% |