Title |
Transgenic Mice Convert Carbohydrates to Essential Fatty Acids
|
---|---|
Published in |
PLOS ONE, May 2014
|
DOI | 10.1371/journal.pone.0097637 |
Pubmed ID | |
Authors |
Victor J. Pai, Bin Wang, Xiangyong Li, Lin Wu, Jing X. Kang |
Abstract |
Transgenic mice (named "Omega mice") were engineered to carry both optimized fat-1 and fat-2 genes from the roundworm Caenorhabditis elegans and are capable of producing essential omega-6 and omega-3 fatty acids from saturated fats or carbohydrates. When maintained on a high-saturated fat diet lacking essential fatty acids or a high-carbohydrate, no-fat diet, the Omega mice exhibit high tissue levels of both omega-6 and omega-3 fatty acids, with a ratio of ∼1∶1. This study thus presents an innovative technology for the production of both omega-6 and omega-3 essential fatty acids, as well as a new animal model for understanding the true impact of fat on human health. |
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