| Title |
Relationship between Interleukin-6 Gene Polymorphism and Hippocampal Volume in Antipsychotic-Naïve Schizophrenia: Evidence for Differential Susceptibility?
|
|---|---|
| Published in |
PLOS ONE, May 2014
|
| DOI | 10.1371/journal.pone.0096021 |
| Pubmed ID | |
| Authors |
Sunil Vasu Kalmady, Ganesan Venkatasubramanian, Venkataram Shivakumar, S. Gautham, Aditi Subramaniam, Dania Alphonse Jose, Arindam Maitra, Vasanthapuram Ravi, Bangalore N. Gangadhar |
| Abstract |
Various lines of evidence including epidemiological, genetic and foetal pathogenetic models suggest a compelling role for Interleukin-6 (IL-6) in the pathogenesis of schizophrenia. IL-6 mediated inflammatory response triggered by maternal infection or stress induces disruption of prenatal hippocampal development which might contribute towards psychopathology during adulthood. There is a substantial lack of knowledge on how genetic predisposition to elevated IL-6 expression effects hippocampal structure in schizophrenia patients. In this first-time study, we evaluated the relationship between functional polymorphism rs1800795 of IL-6 and hippocampal gray matter volume in antipsychotic-naïve schizophrenia patients in comparison with healthy controls. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 137 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 132 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 18% |
| Student > Bachelor | 19 | 14% |
| Researcher | 17 | 12% |
| Student > Master | 14 | 10% |
| Other | 8 | 6% |
| Other | 27 | 20% |
| Unknown | 27 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 26% |
| Psychology | 16 | 12% |
| Neuroscience | 14 | 10% |
| Agricultural and Biological Sciences | 13 | 9% |
| Biochemistry, Genetics and Molecular Biology | 11 | 8% |
| Other | 11 | 8% |
| Unknown | 37 | 27% |