| Title |
Genetic Variants in FBN-1 and Risk for Thoracic Aortic Aneurysm and Dissection
|
|---|---|
| Published in |
PLOS ONE, April 2014
|
| DOI | 10.1371/journal.pone.0091437 |
| Pubmed ID | |
| Authors |
Olga A. Iakoubova, Carmen H. Tong, Charles M. Rowland, May M. Luke, Veronica E. Garcia, Joseph J. Catanese, Remo M. Moomiaie, Peter Sotonyi, Gyorgy Ascady, Demitrios Nikas, Panagiotis Dedelias, Maryann Tranquilli, John A. Elefteriades |
| Abstract |
A recent genome wide association study (GWAS) by LeMaire et al. found that two single nucleotide polymorphisms (SNPs), rs2118181 and rs10519177 in the FBN-1 gene (encoding Fibrillin-1), were associated with thoracic aortic dissection (TAD), non-dissecting thoracic aortic aneurysm (TAA), and thoracic aortic aneurysm or dissection (TAAD); the largest effect was observed for the association of rs2118181 with TAD. We investigated whether rs2118181 and rs10519177 were associated with TAD, TAA, and TAAD in the Yale study. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 50% |
| Venezuela, Bolivarian Republic of | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 6% |
| Unknown | 15 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 3 | 19% |
| Student > Doctoral Student | 3 | 19% |
| Student > Postgraduate | 3 | 19% |
| Professor | 2 | 13% |
| Student > Ph. D. Student | 2 | 13% |
| Other | 3 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 69% |
| Biochemistry, Genetics and Molecular Biology | 4 | 25% |
| Agricultural and Biological Sciences | 1 | 6% |