| Title |
Caffeine Mediates Sustained Inactivation of Breast Cancer-Associated Myofibroblasts via Up-Regulation of Tumor Suppressor Genes
|
|---|---|
| Published in |
PLOS ONE, March 2014
|
| DOI | 10.1371/journal.pone.0090907 |
| Pubmed ID | |
| Authors |
Mysoon M. Al-Ansari, Abdelilah Aboussekhra |
| Abstract |
Active cancer-associated fibroblasts (CAFs) or myofibroblasts play important roles not only in the development and progression of breast carcinomas, but also in their prognosis and treatment. Therefore, targeting these cells through suppressing their supportive procarcinogenic paracrine effects is mandatory for improving the current therapies that are mainly targeting tumor cells. To this end, we investigated the effect of the natural and pharmacologically safe molecule, caffeine, on CAF cells and their various procarcinogenic effects. |
X Demographics
The data shown below were collected from the profiles of 102 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 40 | 39% |
| Canada | 3 | 3% |
| United States | 2 | 2% |
| Micronesia, Federated States of | 1 | <1% |
| Kuwait | 1 | <1% |
| Sweden | 1 | <1% |
| Morocco | 1 | <1% |
| United Arab Emirates | 1 | <1% |
| Finland | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 51 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 85 | 83% |
| Practitioners (doctors, other healthcare professionals) | 11 | 11% |
| Scientists | 4 | 4% |
| Unknown | 2 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Spain | 1 | 2% |
| Sri Lanka | 1 | 2% |
| Unknown | 51 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 19% |
| Student > Ph. D. Student | 8 | 15% |
| Student > Bachelor | 7 | 13% |
| Researcher | 5 | 9% |
| Professor > Associate Professor | 4 | 7% |
| Other | 6 | 11% |
| Unknown | 14 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 15 | 28% |
| Biochemistry, Genetics and Molecular Biology | 10 | 19% |
| Medicine and Dentistry | 7 | 13% |
| Chemistry | 2 | 4% |
| Immunology and Microbiology | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 16 | 30% |