| Title |
Hepatocyte Produced Matrix Metalloproteinases Are Regulated by CD147 in Liver Fibrogenesis
|
|---|---|
| Published in |
PLOS ONE, July 2014
|
| DOI | 10.1371/journal.pone.0090571 |
| Pubmed ID | |
| Authors |
Sarah R. Calabro, Annette E. Maczurek, Alison J. Morgan, Thomas Tu, Victoria W. Wen, Christine Yee, Auvro Mridha, Maggie Lee, William d'Avigdor, Stephen A. Locarnini, Geoffrey W. McCaughan, Fiona J. Warner, Susan V. McLennan, Nicholas A. Shackel |
| Abstract |
The classical paradigm of liver injury asserts that hepatic stellate cells (HSC) produce, remodel and turnover the abnormal extracellular matrix (ECM) of fibrosis via matrix metalloproteinases (MMPs). In extrahepatic tissues MMP production is regulated by a number of mechanisms including expression of the glycoprotein CD147. Previously, we have shown that CD147 is expressed on hepatocytes but not within the fibrotic septa in cirrhosis [1]. Therefore, we investigated if hepatocytes produce MMPs, regulated by CD147, which are capable of remodelling fibrotic ECM independent of the HSC. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 59 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 27% |
| Researcher | 9 | 15% |
| Student > Bachelor | 7 | 12% |
| Student > Master | 5 | 8% |
| Student > Doctoral Student | 5 | 8% |
| Other | 8 | 13% |
| Unknown | 10 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 22% |
| Medicine and Dentistry | 12 | 20% |
| Biochemistry, Genetics and Molecular Biology | 8 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 10% |
| Immunology and Microbiology | 3 | 5% |
| Other | 7 | 12% |
| Unknown | 11 | 18% |