| Title |
Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System
|
|---|---|
| Published in |
PLOS ONE, March 2014
|
| DOI | 10.1371/journal.pone.0089566 |
| Pubmed ID | |
| Authors |
John M. McPartland, Geoffrey W. Guy, Vincenzo Di Marzo |
| Abstract |
The "classic" endocannabinoid (eCB) system includes the cannabinoid receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and their metabolic enzymes. An emerging literature documents the "eCB deficiency syndrome" as an etiology in migraine, fibromyalgia, irritable bowel syndrome, psychological disorders, and other conditions. We performed a systematic review of clinical interventions that enhance the eCB system--ways to upregulate cannabinoid receptors, increase ligand synthesis, or inhibit ligand degradation. |
X Demographics
The data shown below were collected from the profiles of 83 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 22 | 27% |
| United Kingdom | 10 | 12% |
| Canada | 7 | 8% |
| France | 2 | 2% |
| Indonesia | 1 | 1% |
| Finland | 1 | 1% |
| Italy | 1 | 1% |
| Romania | 1 | 1% |
| Montenegro | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 36 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 69 | 83% |
| Practitioners (doctors, other healthcare professionals) | 7 | 8% |
| Scientists | 4 | 5% |
| Science communicators (journalists, bloggers, editors) | 2 | 2% |
| Unknown | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 574 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | <1% |
| Netherlands | 2 | <1% |
| Italy | 1 | <1% |
| Hungary | 1 | <1% |
| United Kingdom | 1 | <1% |
| Australia | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 561 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 80 | 14% |
| Student > Bachelor | 80 | 14% |
| Student > Ph. D. Student | 64 | 11% |
| Student > Master | 62 | 11% |
| Other | 44 | 8% |
| Other | 133 | 23% |
| Unknown | 111 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 145 | 25% |
| Agricultural and Biological Sciences | 48 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 36 | 6% |
| Nursing and Health Professions | 35 | 6% |
| Psychology | 34 | 6% |
| Other | 142 | 25% |
| Unknown | 134 | 23% |