Title |
The miR-17∼92a Cluster of MicroRNAs Is Required for the Fitness of Foxp3+ Regulatory T Cells
|
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Published in |
PLOS ONE, February 2014
|
DOI | 10.1371/journal.pone.0088997 |
Pubmed ID | |
Authors |
Jarrod P. J. Skinner, Ashleigh A. Keown, Mark M. W. Chong |
Abstract |
By genetic inactivation of key microRNA biogenesis enzymes, we and others have previously demonstrated the critical requirement of the microRNA pathway for the differentiation and function of Foxp3(+) regulatory T cells. In this study, we identified members of the miR-17 ∼ 92a cluster of microRNAs to be enriched in regulatory T cells. To investigate the function of this microRNA cluster, we deleted the gene specifically in Foxp3(+) cells in mice. We found that miR-17 ∼ 92a is required for the fitness of regulatory T cells, and deficiency impacted at the level of apoptosis and proliferation of these cells. This led to a loss of Foxp3(+) cells over time, particularly in competitive settings, and culminated in a range of immunologic perturbations. Thus, miR-17 ∼ 92a-target interactions are part of the essential microRNA networks that safeguard the regulatory T cell lineage. |
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