Vinata Vedam-Mai, Bronwen Gardner, Michael S. Okun, Florian A. Siebzehnrubl, Monica Kam, Palingu Aponso, Dennis A. Steindler, Anthony T. Yachnis, Dan Neal, Brittany U. Oliver, Sean J. Rath, Richard L. M. Faull, Brent A. Reynolds, Maurice A. Curtis

Deep brain stimulation (DBS) has been used for more than a decade to treat Parkinson's disease (PD); however, its mechanism of action remains unknown. Given the close proximity of the electrode trajectory to areas of the brain known as the "germinal niches," we sought to explore the possibility that DBS influences neural stem cell proliferation locally, as well as more distantly.