Title |
Methods to Assess the Impact of Mass Oral Cholera Vaccination Campaigns under Real Field Conditions
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Published in |
PLOS ONE, February 2014
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DOI | 10.1371/journal.pone.0088139 |
Pubmed ID | |
Authors |
Jacqueline Deen, Mohammad Ali, David Sack |
Abstract |
There is increasing interest to use oral cholera vaccination as an additional strategy to water and sanitation interventions against endemic and epidemic cholera. There are two internationally-available and WHO-prequalified oral cholera vaccines: an inactivated vaccine containing killed whole-cells of V. cholerae O1 with recombinant cholera toxin B-subunit (WC/rBS) and a bivalent inactivated vaccine containing killed whole cells of V. cholerae O1 and V. cholerae O139 (BivWC). The efficacy, effectiveness, direct and indirect (herd) protection conferred by WC/rBS and BivWC are well established. Yet governments may need local evidence of vaccine impact to justify and scale-up mass oral cholera vaccination campaigns. We discuss various approaches to assess oral cholera vaccine protection, which may be useful to policymakers and public health workers considering deployment and evaluation of the vaccine. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 1 | 25% |
Switzerland | 1 | 25% |
Canada | 1 | 25% |
United States | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 50% |
Scientists | 1 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 45 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 12 | 26% |
Student > Ph. D. Student | 11 | 24% |
Researcher | 7 | 15% |
Other | 4 | 9% |
Student > Bachelor | 3 | 7% |
Other | 5 | 11% |
Unknown | 4 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 33% |
Nursing and Health Professions | 6 | 13% |
Immunology and Microbiology | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Agricultural and Biological Sciences | 2 | 4% |
Other | 12 | 26% |
Unknown | 6 | 13% |