Title |
Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis
|
---|---|
Published in |
PLOS ONE, February 2014
|
DOI | 10.1371/journal.pone.0087366 |
Pubmed ID | |
Authors |
Marilyn D. Skinner, Pierre Lahmek, Héloïse Pham, Henri-Jean Aubin |
Abstract |
Despite its success with compliant or supervised patients, disulfiram has been a controversial medication in the treatment of alcoholism. Often, study designs did not recognize a pivotal factor in disulfiram research, the importance of an open-label design. Our objectives are: (1) to analyze the efficacy and safety of disulfiram in RCTs in supporting abstinence and (2) to compare blind versus open-label studies, hypothesizing that blinded studies would show no difference between disulfiram and control groups because the threat would be evenly spread across all groups. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 2 | 18% |
Japan | 1 | 9% |
France | 1 | 9% |
United States | 1 | 9% |
United Kingdom | 1 | 9% |
Unknown | 5 | 45% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 73% |
Scientists | 2 | 18% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 285 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
Australia | 1 | <1% |
Brazil | 1 | <1% |
Canada | 1 | <1% |
United States | 1 | <1% |
Unknown | 280 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 46 | 16% |
Researcher | 33 | 12% |
Student > Ph. D. Student | 30 | 11% |
Student > Master | 30 | 11% |
Student > Doctoral Student | 24 | 8% |
Other | 60 | 21% |
Unknown | 62 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 75 | 26% |
Psychology | 34 | 12% |
Neuroscience | 17 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 17 | 6% |
Biochemistry, Genetics and Molecular Biology | 14 | 5% |
Other | 46 | 16% |
Unknown | 82 | 29% |