Luping Zhou, Olivier Salvado, Vincent Dore, Pierrick Bourgeat, Parnesh Raniga, S. Lance Macaulay, David Ames, Colin L. Masters, Kathryn A. Ellis, Victor L. Villemagne, Christopher C. Rowe, Jurgen Fripp

β-amyloid (Aβ) plaques in brain's grey matter (GM) are one of the pathological hallmarks of Alzheimer's disease (AD), and can be imaged in vivo using Positron Emission Tomography (PET) with (11)C or (18)F radiotracers. Estimating Aβ burden in cortical GM has been shown to improve diagnosis and monitoring of AD. However, lacking structural information in PET images requires such assessments to be performed with anatomical MRI scans, which may not be available at different clinical settings or being contraindicated for particular reasons. This study aimed to develop an MR-less Aβ imaging quantification method that requires only PET images for reliable Aβ burden estimations.