| Title |
A Phase I Clinical Study of a Live Attenuated Bordetella pertussis Vaccine - BPZE1; A Single Centre, Double-Blind, Placebo-Controlled, Dose-Escalating Study of BPZE1 Given Intranasally to Healthy Adult Male Volunteers
|
|---|---|
| Published in |
PLOS ONE, January 2014
|
| DOI | 10.1371/journal.pone.0083449 |
| Pubmed ID | |
| Authors |
Rigmor Thorstensson, Birger Trollfors, Nabil Al-Tawil, Maja Jahnmatz, Jakob Bergström, Margaretha Ljungman, Anna Törner, Lena Wehlin, Annie Van Broekhoven, Fons Bosman, Anne-Sophie Debrie, Nathalie Mielcarek, Camille Locht |
| Abstract |
Acellular pertussis vaccines do not control pertussis. A new approach to offer protection to infants is necessary. BPZE1, a genetically modified Bordetella pertussis strain, was developed as a live attenuated nasal pertussis vaccine by genetically eliminating or detoxifying 3 toxins. |
X Demographics
The data shown below were collected from the profiles of 19 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 16% |
| Australia | 2 | 11% |
| Nicaragua | 1 | 5% |
| Unknown | 13 | 68% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 74% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
| Scientists | 2 | 11% |
| Unknown | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 112 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 19% |
| Student > Ph. D. Student | 16 | 14% |
| Student > Bachelor | 13 | 11% |
| Student > Master | 12 | 10% |
| Other | 9 | 8% |
| Other | 15 | 13% |
| Unknown | 28 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 19% |
| Immunology and Microbiology | 20 | 17% |
| Agricultural and Biological Sciences | 19 | 17% |
| Biochemistry, Genetics and Molecular Biology | 8 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 8 | 7% |
| Unknown | 34 | 30% |