| Title |
Gene Expression and Functional Annotation of the Human and Mouse Choroid Plexus Epithelium
|
|---|---|
| Published in |
PLOS ONE, December 2013
|
| DOI | 10.1371/journal.pone.0083345 |
| Pubmed ID | |
| Authors |
Sarah F. Janssen, Sophie J. F. van der Spek, Jacoline B. ten Brink, Anke H. W. Essing, Theo G. M. F. Gorgels, Peter J. van der Spek, Nomdo M. Jansonius, Arthur A. B. Bergen |
| Abstract |
The choroid plexus epithelium (CPE) is a lobed neuro-epithelial structure that forms the outer blood-brain barrier. The CPE protrudes into the brain ventricles and produces the cerebrospinal fluid (CSF), which is crucial for brain homeostasis. Malfunction of the CPE is possibly implicated in disorders like Alzheimer disease, hydrocephalus or glaucoma. To study human genetic diseases and potential new therapies, mouse models are widely used. This requires a detailed knowledge of similarities and differences in gene expression and functional annotation between the species. The aim of this study is to analyze and compare gene expression and functional annotation of healthy human and mouse CPE. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 85 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 25% |
| Student > Ph. D. Student | 17 | 20% |
| Student > Master | 9 | 10% |
| Student > Bachelor | 8 | 9% |
| Student > Doctoral Student | 5 | 6% |
| Other | 16 | 18% |
| Unknown | 10 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 19 | 22% |
| Medicine and Dentistry | 17 | 20% |
| Neuroscience | 13 | 15% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Computer Science | 3 | 3% |
| Other | 12 | 14% |
| Unknown | 16 | 18% |