Title |
CyTargetLinker: A Cytoscape App to Integrate Regulatory Interactions in Network Analysis
|
---|---|
Published in |
PLOS ONE, December 2013
|
DOI | 10.1371/journal.pone.0082160 |
Pubmed ID | |
Authors |
Martina Kutmon, Thomas Kelder, Pooja Mandaviya, Chris T. A. Evelo, Susan L. Coort |
Abstract |
The high complexity and dynamic nature of the regulation of gene expression, protein synthesis, and protein activity pose a challenge to fully understand the cellular machinery. By deciphering the role of important players, including transcription factors, microRNAs, or small molecules, a better understanding of key regulatory processes can be obtained. Various databases contain information on the interactions of regulators with their targets for different organisms, data recently being extended with the results of the ENCODE (Encyclopedia of DNA Elements) project. A systems biology approach integrating our understanding on different regulators is essential in interpreting the regulation of molecular biological processes. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 50% |
Netherlands | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 1% |
Netherlands | 2 | 1% |
Italy | 1 | <1% |
India | 1 | <1% |
Switzerland | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Russia | 1 | <1% |
Other | 0 | 0% |
Unknown | 161 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 41 | 24% |
Researcher | 31 | 18% |
Student > Master | 23 | 13% |
Student > Bachelor | 13 | 8% |
Student > Doctoral Student | 11 | 6% |
Other | 31 | 18% |
Unknown | 22 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 52 | 30% |
Biochemistry, Genetics and Molecular Biology | 37 | 22% |
Medicine and Dentistry | 17 | 10% |
Computer Science | 13 | 8% |
Engineering | 6 | 3% |
Other | 18 | 10% |
Unknown | 29 | 17% |