Title |
Gr1intCD11b+ Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection
|
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Published in |
PLOS ONE, November 2013
|
DOI | 10.1371/journal.pone.0080669 |
Pubmed ID | |
Authors |
Andrés Obregón-Henao, Marcela Henao-Tamayo, Ian M. Orme, Diane J. Ordway |
Abstract |
Tuberculosis is one of the world's leading killers, stealing 1.4 million lives and causing 8.7 million new and relapsed infections in 2011. The only vaccine against tuberculosis is BCG which demonstrates variable efficacy in adults worldwide. Human infection with Mycobacterium tuberculosis results in the influx of inflammatory cells to the lung in an attempt to wall off bacilli by forming a granuloma. Gr1(int)CD11b(+) cells are called myeloid-derived suppressor cells (MDSC) and play a major role in regulation of inflammation in many pathological conditions. Although MDSC have been described primarily in cancer their function in tuberculosis remains unknown. During M. tuberculosis infection it is crucial to understand the function of cells involved in the regulation of inflammation during granuloma formation. Understanding their relative impact on the bacilli and other cellular phenotypes is necessary for future vaccine and drug design. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 78 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 23 | 29% |
Student > Ph. D. Student | 14 | 18% |
Student > Master | 10 | 13% |
Student > Bachelor | 4 | 5% |
Other | 4 | 5% |
Other | 14 | 18% |
Unknown | 9 | 12% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 25 | 32% |
Immunology and Microbiology | 17 | 22% |
Medicine and Dentistry | 10 | 13% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Unspecified | 2 | 3% |
Other | 5 | 6% |
Unknown | 12 | 15% |