Title |
Detection of Oseltamivir-Resistant Pandemic Influenza A(H1N1)pdm2009 in Brazil: Can Community Transmission Be Ruled Out?
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Published in |
PLOS ONE, November 2013
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DOI | 10.1371/journal.pone.0080081 |
Pubmed ID | |
Authors |
Thiago Moreno L. Souza, Paola C. Resende, Natalia Fintelman-Rodrigues, Tatiana Schaffer Gregianini, Nilo Ikuta, Sandra Bianchini Fernandes, Ana Luisa Furtado Cury, Maria do Carmo Debur Rosa, Marilda M. Siqueira |
Abstract |
Although surveillance efforts that monitor the emergence of drug-resistant strains of influenza are critical, systematic analysis is overlooked in most developing countries. We report on the occurrence of strains of pandemic influenza A(H1N1)pdm09 with resistance and decreased susceptibility to oseltamivir (OST) in Brazil in 2009, 2011 and 2012. We found 7 mutant viruses, 2 with the mutation S247N and other 5 with the mutation H275Y. Most of these viruses were from samples concentrated in the southern region of Brazil. Some of these resistant viruses were detected prior to the initiation of OST treatment, suggesting that community transmission of mutant viruses may exist. Moreover, we show that one of these OST-resistant (H275Y) strains of A(H1N1)pdm09 was discovered in the tri-border region between Brazil, Argentina and Paraguay, highlighting that this strain could also be found in other Latin American countries. Our findings reinforce the importance of enhanced antiviral resistance surveillance in Brazil and in other Latin American countries to confirm or rule out the community transmission of OST-resistant strains of A(H1N1)pdm09. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 30% |
Student > Bachelor | 7 | 21% |
Student > Master | 3 | 9% |
Professor | 2 | 6% |
Student > Doctoral Student | 1 | 3% |
Other | 3 | 9% |
Unknown | 7 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 21% |
Agricultural and Biological Sciences | 6 | 18% |
Immunology and Microbiology | 4 | 12% |
Medicine and Dentistry | 3 | 9% |
Nursing and Health Professions | 2 | 6% |
Other | 3 | 9% |
Unknown | 8 | 24% |