| Title |
Tumor Mutation Burden Forecasts Outcome in Ovarian Cancer with BRCA1 or BRCA2 Mutations
|
|---|---|
| Published in |
PLOS ONE, November 2013
|
| DOI | 10.1371/journal.pone.0080023 |
| Pubmed ID | |
| Authors |
Nicolai Juul Birkbak, Bose Kochupurakkal, Jose M. G. Izarzugaza, Aron C. Eklund, Yang Li, Joyce Liu, Zoltan Szallasi, Ursula A. Matulonis, Andrea L. Richardson, J. Dirk Iglehart, Zhigang C. Wang |
| Abstract |
Increased number of single nucleotide substitutions is seen in breast and ovarian cancer genomes carrying disease-associated mutations in BRCA1 or BRCA2. The significance of these genome-wide mutations is unknown. We hypothesize genome-wide mutation burden mirrors deficiencies in DNA repair and is associated with treatment outcome in ovarian cancer. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 1 | 20% |
| Germany | 1 | 20% |
| United States | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 3 | 60% |
| Members of the public | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 138 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 35 | 25% |
| Student > Ph. D. Student | 21 | 15% |
| Student > Master | 16 | 11% |
| Student > Bachelor | 14 | 10% |
| Other | 9 | 6% |
| Other | 25 | 18% |
| Unknown | 22 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 35 | 25% |
| Medicine and Dentistry | 34 | 24% |
| Agricultural and Biological Sciences | 29 | 20% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Immunology and Microbiology | 2 | 1% |
| Other | 11 | 8% |
| Unknown | 28 | 20% |