| Title |
Extended Safety, Immunogenicity and Efficacy of a Blood-Stage Malaria Vaccine in Malian Children: 24-Month Follow-Up of a Randomized, Double-Blinded Phase 2 Trial
|
|---|---|
| Published in |
PLOS ONE, November 2013
|
| DOI | 10.1371/journal.pone.0079323 |
| Pubmed ID | |
| Authors |
Matthew B. Laurens, Mahamadou A. Thera, Drissa Coulibaly, Amed Ouattara, Abdoulaye K. Kone, Ando B. Guindo, Karim Traore, Idrissa Traore, Bourema Kouriba, Dapa A. Diallo, Issa Diarra, Modibo Daou, Amagana Dolo, Youssouf Tolo, Mahamadou S. Sissoko, Amadou Niangaly, Mady Sissoko, Shannon Takala-Harrison, Kirsten E. Lyke, Yukun Wu, William C. Blackwelder, Olivier Godeaux, Johan Vekemans, Marie-Claude Dubois, W. Ripley Ballou, Joe Cohen, Tina Dube, Lorraine Soisson, Carter L. Diggs, Brent House, Jason W. Bennett, David E. Lanar, Sheetij Dutta, D. Gray Heppner, Christopher V. Plowe, Ogobara K. Doumbo |
| Abstract |
The FMP2.1/AS02A candidate malaria vaccine was tested in a Phase 2 study in Mali. Based on results from the first eight months of follow-up, the vaccine appeared well-tolerated and immunogenic. It had no significant efficacy based on the primary endpoint, clinical malaria, but marginal efficacy against clinical malaria in secondary analyses, and high allele-specific efficacy. Extended follow-up was conducted to evaluate extended safety, immunogenicity and efficacy. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| India | 1 | 1% |
| Unknown | 92 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 20% |
| Student > Master | 11 | 12% |
| Student > Bachelor | 9 | 10% |
| Researcher | 8 | 9% |
| Student > Postgraduate | 4 | 4% |
| Other | 13 | 14% |
| Unknown | 30 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 23% |
| Medicine and Dentistry | 16 | 17% |
| Immunology and Microbiology | 5 | 5% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Nursing and Health Professions | 4 | 4% |
| Other | 11 | 12% |
| Unknown | 32 | 34% |