Title |
IL-33, but Not IL-25, Is Crucial for the Development of House Dust Mite Antigen-Induced Allergic Rhinitis
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Published in |
PLOS ONE, October 2013
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DOI | 10.1371/journal.pone.0078099 |
Pubmed ID | |
Authors |
Wakako Nakanishi, Sachiko Yamaguchi, Akira Matsuda, Maho Suzukawa, Akiko Shibui, Aya Nambu, Kenji Kondo, Hajime Suto, Hirohisa Saito, Kenji Matsumoto, Tatuya Yamasoba, Susumu Nakae |
Abstract |
Both interleukin (IL)-33 and IL-25 induce Th2 cytokine production by various cell types, suggesting that they contribute to development of allergic disorders. However, the precise roles of IL-33 and IL-25 in house dust mite (HDM)-induced allergic rhinitis (AR) remain unclear. Both IL-33 and IL-25 were produced mainly by nasal epithelial cells during HDM-induced AR. Eosinophil and goblet cell counts in the nose and IL-5 levels in lymph node cell culture supernatants were significantly decreased in IL-33-deficient, but not IL-25-deficient, mice compared with wild-type mice during HDM-induced AR, but the serum IgE and IgG1 levels did not differ. On the other hand, HDM-induced AR developed similarly in wild-type mice transferred with either IL-33-deficient BM cells or wild-type BM cells. IL-33, but not IL-25, produced by nasal epithelial cells was crucial for the development of murine HDM-induced AR. These observations suggest that IL-33 neutralization may be a potential approach for treatment of HDM-induced AR in humans. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 60 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 18% |
Student > Master | 10 | 17% |
Student > Ph. D. Student | 9 | 15% |
Student > Doctoral Student | 5 | 8% |
Student > Bachelor | 3 | 5% |
Other | 10 | 17% |
Unknown | 12 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 20% |
Immunology and Microbiology | 11 | 18% |
Biochemistry, Genetics and Molecular Biology | 6 | 10% |
Neuroscience | 2 | 3% |
Other | 3 | 5% |
Unknown | 11 | 18% |