| Title |
Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect
|
|---|---|
| Published in |
PLOS ONE, October 2013
|
| DOI | 10.1371/journal.pone.0076918 |
| Pubmed ID | |
| Authors |
Marta Solinas, Paola Massi, Valentina Cinquina, Marta Valenti, Daniele Bolognini, Marzia Gariboldi, Elena Monti, Tiziana Rubino, Daniela Parolaro |
| Abstract |
In the present study, we found that CBD inhibited U87-MG and T98G cell proliferation and invasiveness in vitro and caused a decrease in the expression of a set of proteins specifically involved in growth, invasion and angiogenesis. In addition, CBD treatment caused a dose-related down-regulation of ERK and Akt prosurvival signaling pathways in U87-MG and T98G cells and decreased hypoxia inducible factor HIF-1α expression in U87-MG cells. Taken together, these results provide new insights into the antitumor action of CBD, showing that this cannabinoid affects multiple tumoral features and molecular pathways. As CBD is a non-psychoactive phytocannabinoid that appears to be devoid of side effects, our results support its exploitation as an effective anti-cancer drug in the management of gliomas. |
X Demographics
The data shown below were collected from the profiles of 96 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 23 | 24% |
| Japan | 6 | 6% |
| Canada | 3 | 3% |
| Mexico | 3 | 3% |
| Russia | 3 | 3% |
| Montenegro | 1 | 1% |
| Ireland | 1 | 1% |
| Georgia | 1 | 1% |
| Chile | 1 | 1% |
| Other | 9 | 9% |
| Unknown | 45 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 90 | 94% |
| Science communicators (journalists, bloggers, editors) | 3 | 3% |
| Practitioners (doctors, other healthcare professionals) | 2 | 2% |
| Scientists | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 205 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| United Kingdom | 1 | <1% |
| Singapore | 1 | <1% |
| Unknown | 199 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 27 | 13% |
| Researcher | 26 | 13% |
| Student > Ph. D. Student | 24 | 12% |
| Student > Bachelor | 20 | 10% |
| Other | 13 | 6% |
| Other | 32 | 16% |
| Unknown | 63 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 14% |
| Medicine and Dentistry | 27 | 13% |
| Agricultural and Biological Sciences | 27 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 7% |
| Chemistry | 10 | 5% |
| Other | 26 | 13% |
| Unknown | 71 | 35% |