Title |
Effects of Short-Term Nutritional Interventions on Right Ventricular Function in Healthy Men
|
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Published in |
PLOS ONE, September 2013
|
DOI | 10.1371/journal.pone.0076406 |
Pubmed ID | |
Authors |
Ralph L. Widya, Sebastiaan Hammer, Mariëtte R. Boon, Rutger W. van der Meer, Johannes W. A. Smit, Albert de Roos, Patrick C. N. Rensen, Hildo J. Lamb |
Abstract |
A physiological model of increased plasma nonesterified fatty acid (NEFA) levels result in myocardial triglyceride (TG) accumulation, which is related to cardiac dysfunction. A pathophysiological model of increased plasma NEFA levels result in hepatic steatosis, which has been linked to abnormal myocardial energy metabolism. Hepatic steatosis is accompanied by hepatic inflammation, reflected by plasma cholesteryl ester transfer protein (CETP) levels. The current study aimed to investigate effects of these models via different nutritional interventions on right ventricular (RV) function. |
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