| Title |
Proteomic Analysis of Signaling Network Regulation in Renal Cell Carcinomas with Differential Hypoxia-Inducible Factor-2α Expression
|
|---|---|
| Published in |
PLOS ONE, August 2013
|
| DOI | 10.1371/journal.pone.0071654 |
| Pubmed ID | |
| Authors |
Lokesh Dalasanur Nagaprashantha, Tatjana Talamantes, Jyotsana Singhal, Jia Guo, Rit Vatsyayan, Navin Rauniyar, Sanjay Awasthi, Sharad S. Singhal, Laszlo Prokai |
| Abstract |
The loss of von Hippel-Lindau (VHL) protein function leads to highly vascular renal tumors characterized by an aggressive course of disease and refractoriness to chemotherapy and radiotherapy. Loss of VHL in renal tumors also differs from tumors of other organs in that the oncogenic cascade is mediated by an increase in the levels of hypoxia-inducible factor-2α (HIF2α) instead of hypoxia-inducible factor-1α (HIF1α). |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 21% |
| Student > Ph. D. Student | 7 | 16% |
| Student > Master | 6 | 14% |
| Student > Bachelor | 4 | 9% |
| Other | 3 | 7% |
| Other | 9 | 21% |
| Unknown | 5 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 30% |
| Medicine and Dentistry | 10 | 23% |
| Biochemistry, Genetics and Molecular Biology | 4 | 9% |
| Computer Science | 3 | 7% |
| Engineering | 2 | 5% |
| Other | 5 | 12% |
| Unknown | 6 | 14% |