Takeshi Chiyomaru, Soichiro Yamamura, Shinichiro Fukuhara, Hirofumi Yoshino, Takashi Kinoshita, Shahana Majid, Sharanjot Saini, Inik Chang, Yuichiro Tanaka, Hideki Enokida, Naohiko Seki, Masayuki Nakagawa, Rajvir Dahiya

Genistein is a soy isoflavone that has antitumor activity both in vitro and in vivo. It has been shown that genistein inhibits many type of cancers including prostate cancer (PCa) by regulating several cell signaling pathways and microRNAs (miRNAs). Recent studies suggest that the long non-coding RNAs (lncRNAs) are also involved in many cellular processes. At present there are no reports about the relationship between gensitein, miRNAs and lncRNAs. In this study, we focused on miRNAs, lncRNA that are regulated by genistein and investigated their functional role in PCa.